Sedative-Hypnotics (Part 02) = Classification and Mechanism of Action of Benzodiazepine | Sedative
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A sedative is those drugs which make the patient calm and relax without causing sleep, although the patient may feel dizziness and may lose alertness or responsiveness. Hypnotics are the drugs which make a person calm but also induce sleep. This is an extension of a sedative dose of any drugs. Sedative in large dose act as hypnotics. The target of Benzodiazepine is on GABA receptor because GABA is a major inhibitory neurotransmitter in CNS. GABA is consisting of five- alpha, beta, gamma subunits that span the postsynaptic membrane. The influx of chloride Ions cause hyperpolarization of the neuron and decrease neurotransmitter by inhibiting the formation of action potentials.
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